Histological pattern and changes in extracellular matrix in aortic dissections.

Histological pattern and changes in extracellular matrix in aortic dissections.

Samples from 34 patients were studied both histologically and immunocytochemically by the indirect biotin-avidin peroxidase technique to analyse the distribution of the extracellular matrix components (type IV collagen, fibronectin, types I and III collagens) in dissection of the aorta. Most showed defects in type IV collagen around medial smooth muscle cells. Defects in smooth muscle cell base...

Vascular extracellular matrix and aortic development.

Adventitial Fibroblast Abormality in Thoracic Aortic Aneurysms and Aortic Dissections

BACKGROUND Development of thoracic aortic aneurysms and aortic dissections (TAAD) is attributed to unbearable wall tension superimposed on defective aortic wall integrity and impaired aortic repair mechanisms. Central to this repair mechanisms are well-balanced and adequately functional cellular components of the aortic wall, including endothelial cells, smooth muscle cells (SMCs), inflammatory...

Postmortem Changes in Muscle Extracellular Matrix Proteins

It has long been recognized that meat tenderness is related to both the components inside the muscle fibers (predominantly the myofibril) and the connective tissues surrounding the fibers (predominantly collagen). It has also been shown that the tenderness of meat increases with time of storage postmortem. Most work attempting to determine the mechanism of this postmortem tenderization has conc...

Extracellular matrix changes in urethral stricture disease.

PURPOSE Glycosaminoglycans (GAGs) and collagen are major components of the extracellular matrix and they have key roles in fibrotic diseases. Little is known about the molecular environment in urethral stricture and the majority of the studies available focused on collagen analysis. However, to our knowledge there are no data on GAG composition in urethral stricture disease. MATERIALS AND MET...